Tapentadol is an opioid drug (also called a narcotic). It is a strong painkiller that is used to treat moderate or severe levels of pain. This drug is not recommended for the treatment of chronic pain. It works in the brain to change how your body feels and responds to pain and displays a stronger analgesic effect superior to that of classical opioids such as oxycodone and morphine.

Tapentadol comes as a tablet and an extended-release (long-acting) tablet to be taken by mouth. The tablets are usually taken with or without food every 4 to 6 hours as needed.  The frequency of usage of the tapentadol tablets can be as often as an hour after the first dose.

The extended-release tablets are taken only once in 12 hours and are not to be repeated within that timeframe.

Ensure you follow the directions on your prescription label carefully, or your doctor’s prescription.

Tapentadol comes in 50mg, 75mg, 100mg doses and in oral tablet forms.

Tapentadol is used in the treatment of moderate or severe pain that isn’t responsive to non-opioid medications.

Tapentadol is a centrally acting analgesic that has a dual mechanism of action. It works by binding to mu-opioid receptors in the central nervous system and also inhibits the reuptake of noradrenaline. This affects the way the body receives pain signals and how it also responds to them.

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Tapentadol shows a relatively lower risk for abuse, diversion, and dependence compared to other opioids. However, there are still major concerns for tapentadol abuse, addiction, seeking behavior, withdrawal, and physical dependence.

As with all opioids, there are mild, as well as fatal side effects. for Tapentadol, the incidence of these side effects increases with an increased concentration or prolonged usage. The common side effects include nausea, digestive problems such as constipation or vomiting, dizziness, drowsiness, and headache. The fatal side effects which can result from long-term usage of the drug include:

  • mental or physical dependence
  • liver damage
  • Stiffness of muscles or ‘jerky’ movements
  • Tachycardia
  • Anxiety
  • Noisy breathing, shallow breathing or breathing that stops

Tapentadol stays about one (1) day in the blood. Drug metabolism and excretion from the body can last as long as 3-4 days It also stays in the hair longer. Drug tests on one’s hair can show traces of tapentadol for up to 90 days after the last dose.

The most suitable form of tapentadol for the treatment of chronic pain is the extended-release form. This around-the-clock release of the drug provides constant levels of the concentration of the drug in the body that is sufficient to keep chronic pain at bay and in time treat the underlying cause of the pain.

Tapentadol’s extended-release form is a long-acting form of the drug that is used for around-the-clock treatment of pain that is not controlled by other medications. The extended-release form of tapentadol is not for pain use on an as-needed basis.

Tapentadol tablets are used to treat moderate to severe acute pain. It can be used by patients who suffer from low back pain and is sometimes administered for post-surgical analgesia. Tapentadol extended-release tablets are used to treat severe neuropathic pain (pain caused by nerve damage) in people who have diabetes.

Muscle relaxants are drugs that reduce muscle tone and can be used to alleviate symptoms of muscle spasm, twitching, soreness, and ache. This term is used broadly used for neuromuscular blockers and spasmolytics. Neuromuscular blockers act by intercepting synaptic transmission at the neuromuscular junctions in the body. Spasmolytics, on the other hand, also known as “centrally acting” muscle relaxants, are used to alleviate musculoskeletal pain and spasms.

Soreness and pain in the back and neck can be uncomfortable and progressively lead to more discomfort that can hamper one’s regular day-to-day activities. Muscle relaxants such as Soma (carisoprodol), Flexeril (cyclobenzaprine), and Valium (diazepam) are used to treat back and neck pain and can be used to effectively treat these symptoms and alleviate such discomfort.

What is Carisoprodol?

Carisoprodol is a generic variant of the brand-name drug Soma. It is a carbamate-based muscle relaxant used alongside physical therapy, rest, and other measures to alleviate muscle pain and discomfort. It is a centrally acting muscle relaxant that is prescribed for the treatment of acute muscle pain.

In the United States, this drug is classified as a Schedule IV drug, which means that it is a controlled substance and has the potential for abuse (similar to Xanax, Valium, and Ativan).

This medication is only taken for up to three weeks since there has been no evidence of continued effectiveness after 3 weeks. It is safe for use in people between the ages of 17-64 and is not recommended for use in those below the age of 16 and folks above 65.

The common side effects of Carisoprodol are headache, dizziness, and drowsiness which go away n a few days to a couple of weeks in mild cases. The more serious side effects of this medication include:

  • Cardiovascular disturbances and symptoms can include:
    • tachycardia
    • Hypotension and possibly, fainting
    • Redness of the face
  • Nervous system problems present as:
    • Agitation or trembling
    • Seizures
    • Depression
    • Inability to control muscle function
  • Gastrointestinal disturbances which can include:
    • Abdominal pain
    • Nausea
    • Vomiting
  • Blood problems, such as:
    • Decrease in white blood cells or other types of blood cells which lead to a high risk of infection.

Dosage for muscle pain

Adult dosage (ages 17 to 64 years)

Typical dosage: 250–350 mg, three times per day and at bedtime. This is a total of four times per day (1,400 mg/day).

Child dosage (ages 0 to 16 years)

This medication hasn’t been studied in children below the age of 17 and in adults older than 65 years. It shouldn’t be used in people of this age group.

While it varies for each person, Carisoprodol usually stays effective in the body system for an average of 11 hours. Metabolites of this drug may remain for up to four days after you stop taking it. Standard drug tests do not screen for Soma, so it is only detectable if a person is specifically tested for it.

Carisoprodol acts to reduce muscle tone and reduce muscle spasms. It also alleviates pain and aches in the muscles. It is also used to treat back and neck pain and alleviate such discomfort.

Carisoprodol is available as an oral medication, i.e. it is taken from the mouth. There are no studies to show the efficacy and possible dangers associated with taking this drug via the nasal route, hence, it should only be taken via the oral route.

Muscle relaxants like Carisoprodol and benzodiazepines (diazepam) are usually prescribed for low back pain (LBP) when non-steroidal anti-inflammatory drugs are ineffective. They produce symptomatic relief for acute and chronic LBP. The use of muscle relaxants for low back pain continues to be a source of controversy amongst physicians, mainly because of their side effects which can range from mild headaches to seizures.

Soma is an effective muscle relaxant but its use is limited by its side effects, potential for abuse and the duration of action which is a few hours and requires repetitive usage. Soma also produces stronger sedative effects than other muscle relaxants.

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The recommended dose (unless otherwise stated by a physician) of carisoprodol tablets, USP is 250 mg to 350 mg three times a day and at bedtime. However, depending on the weight of the person and the response to the medication, this dosage can either be lower or higher. The recommended maximum duration of carisoprodol tablets, USP use is up to two or three weeks.